Publications

  •   Nozaki K#, Miao EA#. Bucket lists must be completed during cell death. Trends Cell Biol. 2023 Mar 22:S0962-8924(23)00040-5. doi: 10.1016/j.tcb.2023.02.008.

    # Corresponding authors

  • Nozaki K*, Maltez VI*, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA. Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967. doi: 10.1038/s41586-022-04825-8. Epub 2022 Jun 15.

    * These authors contributed equally.

  • Nozaki K, Li L, Miao EA. Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection. Annu. Rev. Immunol. 2022. 2022 Feb 9. doi: 10.1146/annurev-immunol-101320-011235.

  • Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T. Co-culture with Intestinal Epithelial Organoids Allows Efficient Expansion and Motility Analysis of Intraepithelial Lymphocytes. J Gastroenterol. 2016 Mar;51(3):206-13.Our services

  •   Wei B, Billman ZP, Nozaki K, Goodridge HS, Miao EA. NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns. Front Immunol. 2024 Jul 15;15:1418290. doi: 10.3389/fimmu.2024.1418290. eCollection 2024.

  • Nozaki K#, Miao EA#. Bucket lists must be completed during cell death. Trends Cell Biol. 2023 Mar 22:S0962-8924(23)00040-5. doi: 10.1016/j.tcb.2023.02.008.

    # Corresponding authors

  • Nozaki K*, Maltez VI*, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA. Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967. doi: 10.1038/s41586-022-04825-8. Epub 2022 Jun 15.

    * These authors contributed equally.

    → Also see Spotlight: Zhou JY & Fitzgerald KA, Hold your horses! Reining in your fastest pores with caspase-7. Immunity (2022) PMID 35947978.

    → Also see Research Highlight: Jin, K., Shen, G. Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores. Sig Transduct Target Ther 7, 293 (2022).

  • Barclay WE, Aggarwal N, Deerhake ME, Inoue M, Nonaka T, Nozaki K, Luzum N, Miao EA, Mari L. Shinohara ML. The AIM2 inflammasome is activated in astrocytes during the late phase of EAE. JCI Insight. 2022 Apr 22;7(8):e155563.

  • Nozaki K, Li L, Miao EA. Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection. Annu. Rev. Immunol. 2022. 2022 Feb 9. doi: 10.1146/annurev-immunol-101320-011235. Online ahead of print.

  •   Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nozaki K, Mizutani T, Nakamura T, Watanabe M, Okamoto R. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021;11(5):1483-1503.

  •   Nozaki K, Miao EA. A licence to kill during inflammation. Nature. 2019 Jun;570(7761):316-317.

  •   Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T. Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection. Biol Open. 2017 Sep 15;6(9):1364-1374.

  •   Matsumoto T, Mochizuki W, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS One. 2016 Aug 26;11(8):e0162049.

  • Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T. Co-culture with Intestinal Epithelial Organoids Allows Efficient Expansion and Motility Analysis of Intraepithelial Lymphocytes. J Gastroenterol. 2016 Mar;51(3):206-13.

    → Also see Editorial: Mizoguchi A, A novel intestinal organoid-based in vitro co-culture system to dissect out the initial host defense system. J Gastroenterol. 2017 Jan;52(1):123-124.

  • Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Ma A, Watanabe M. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015 Jul 3;11(7):1052-62.

  • Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014 Aug 15;28(16):1752-7.

  • Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem Biophys Res Commun. 2012 Mar 9;419(2):238-43.

  • Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M. Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm Bowel Dis. 2008 Dec;14(12):1630-40